first successful pregnancies following embryo selection using time-lapse technology in iran: case report

background: embryo selection is a vital part of in vitro fertilization (ivf) programs, with morphology-based grading systems having been widely used for decades. time-lapse imaging combined with embryo morph kinetics may proffer a non-invasive means for improving embryo selection. we report the first ongoing and chemical pregnancies using time-lapse embryo scope to select best embryos for transfer in iran. cases: a case with tubal factor infertility was admitted to ivf program with normozoospermia. after ovarian hyper stimulation, 6 cocs were retrieved and inseminated with 25,000 progressive sperms/ oocyte. five zygotes were placed individually into the micro wells of equilibrated embryo scope dish for time-lapse observation, and incubated at 37°c, 5% co2. on day 3, single embryo transfer (set) took place based on kinetic parameters of the embryos. clinical pregnancy was confirmed 7 weeks after set. the second case with history of previous icsi failure was admitted with azoospermia. nine mii oocytes underwent icsi, and incubated in time-lapse facilities. the rest of procedures were followed as described for case 1. chemical pregnancy was confirmed 15 days after set. conclusion: this approach opens a way to select best embryo non-invasively for set; thus, increasing implantation, while reducing multiple pregnancy complications.